Williams hasn't played since winning the Australian Open in January. In two tournaments this year—she played the warm-up event in Auckland prior to the season's first major—Williams is 8-1, her lone defeat coming to countrywoman Madison Brengle.
Williams, 35, boycotted the tournament from 2001 until 2015 after an ugly incident at the turn of the century in which she felt the crowd verbally abused and racially targeted her. She won the tournament in 1999 and 2001, and lost to Victoria Azarenka, 6-4, 6-4, in the final last year.
Kerber is now the top seed, and is followed by Karolina Pliskova, Simona Halep and Dominika Cibulkova.