Game, Set, Bet: Pegula, Keys, Zheng the betting favorites at Credit One Charleston Open

The Credit One Charleston Open isn’t a 1000-level event, but it’s a clay-court 500 with a rich history. That’s why we typically see some great fields, and the 2025 tournament is no exception. Three the world’s Top 10 will be competing at LTP-Daniel Island this week, and there are several other players with the ability to make some magic happen this year.

Make sure you’re checking out our tennis betting content throughout the week, as we’ll providing you with daily best bets in the form of our Pick of the Day series. And, now, some insights on the three betting favorites in South Carolina.

Credit One Charleston Open Odds (BetMGM)

• Jessica Pegula (+500)
• Madison Keys (+500)
• Qinwen Zheng (+550)
• Amanda Anisimova (+700)
• Belinda Bencic (+800)
• Danielle Collins (12-1)
• Emma Navarro (16-1)
• Daria Kasatkina (16-1)
• Diana Shnaider (20-1)
• Ashlyn Krueger (20-1)

For more Credit One Charleston Open odds, *head over to BetMGM*

Credit One Charleston Open Favorites

Jessica Pegula (+500): Pegula must be a little deflated entering this tournament, as she lost in the final of the Miami Open. She has now come up short against Aryna Sabalenka in three American hard-court finals, and she has to be wondering what she’ll need to do to get over the hump. The good news for the world No. 4 is that Sabalenka isn’t playing in Charleston. Also, if she’s looking for a little change in scenery, perhaps she’ll be energized moving from hard courts to clay. Pegula missed a good chunk of the clay-court season last year, as she was banged up and wanted to make sure she was fully healthy for grass season. But she has always been dangerous on this surface, and she was a semifinalist in Charleston last year.

Madison Keys (+500): Keys has been an absolute force in 2025, going 19-3 and winning the Australian Open. Her racquet change has made her a little more accurate as a ball-striker, but she still has world-class power. On top of that, the changes she has made to her service motion have made her an even more dangerous server, which is impressive considering she has always been good in that regard.

As we turn the page to clay season, Keys should remain a constant at the top of the women’s game. While the American just won her first major on a hard court, her 62.4% win percentage on clay is actually higher than that on hard courts—60.8%. Keys is just as dangerous as a returner, as she has all kinds of power. That goes up a notch on clay, with higher bounces giving her more time to unload. She also has a little more time to set her feet with her groundstrokes. On top of all of that, Keys was a semifinalist in Charleston in 2015, and she also won this event in 2019. Don’t be surprised if the American picks up her third title of 2025 in the Palmetto State.

Qinwen Zheng (+550): We haven’t seen the best of Zheng this season, but she looked a little better at the Miami Open than she did earlier in the year. She just ran into the same problem that Pegula did: Sabalenka. Well, with the Belarusian not in the field, Zheng should feel like there’s an opportunity for her to get back in the winner’s circle. And while most of Zheng’s WTA-level success has come on hard courts, she’s a very strong 34-13 on clay. She also won a gold medal at Roland Garros last summer, and her second straight title in Palermo. This could be the week Zheng needs to put herself together and get hot before the European clay swing.