Can power couple Madison Keys, Bjorn Fratangelo score a US Open mixed doubles victory?

WATCH: Can Keys' recent singles success—including a run to the Western & Southern Open semifinals—translate to a mixed major win?

It might fall behind the gender-specific singles and doubles categories at the Grand Slams when it comes to prestige, but one has to admit: Mixed doubles definitely does alright when it comes to generating the headlines.

Naomi tweets out that she might play. Coco searches for a partner online, ends up with Sock and almost wins a Slam. Who will Kyrgios play with, if he decides to go for it? It only happens a few times a year that the men and women will team up, and it appears to be an enjoyable experience for all involved. These five teams will be bringing the star power and the storylines to the court as they aim for Grand Slam glory in New York in the days ahead.

Madison Keys and Bjorn Fratangelo

Singles is more of a thing for the American pair on the court, even though they’ve been a doubles team off it for a few years now. As told to the ATP last year, Fratangelo finally wore Keys down as far as playing mixed goes, when the pair made their US Open debut. Though they lost in the first round, they clearly had fun on the court—so much so that they’re going for it again this year.

Victoria Azarenka and Thanasi Kokkinakis

Before she won two Australian Open singles titles and reached the final of the US Open three times, Azarenka first got a taste of Grand Slam glory way back in 2007 when she won the mixed in New York with countryman Max Mirnyi. She's teaming up with a fairly new major champion in Kokkinakis, who won the men's doubles on home soil in Melbourne with Nick Kyrgios. Kokkinakis' singles campaign took a quick hit so he'll surely be eager to stick around in New York a bit longer.

Laura Siegemund and Jamie Murray

From 2017 to ’19, Murray was running roughshod over the mixed doubles draw and having a grand old time with Martina Hingis and Bethanie Mattek-Sands, picking up three straight titles. This year, he’s partnering with Siegemund, who’s always up for a battle and has her own experience with winning majors in New York: The German preceded Murray as a mixed doubles champ in 2016 and won the women’s doubles with Vera Zvonareva in 2020.

Desirae Krawczyk and Neal Skupski

When it comes to mixed, Krawczyk is aiming for GOAT status. The American has won four titles in her last seven Slams, two of them with Skupski (the other two came with another Brit, Joe Salisbury). Krawczyk and Skupski are the top seeds, and deservedly so: They’re coming off their second straight Wimbledon victory in their most recent major appearance. Krawczyk is aiming for another title defense over the next two weeks.

Leylah Fernandez and Jack Sock

It’s become a bit of a given over the years: When a player teams up with Sock—in men’s or mixed—there’s a pretty good chance you’re going to be in the running for a title. Though Fernandez might not have the doubles experience as some of Sock’s other partners, the young Canadian is as fiery a competitor as they come. Combine that with Sock’s versatility and you have what’s sure to be an entertaining pair.

What may keep this team from getting off the ground is Sock’s health: up two sets against Diego Schwartzman in men’s singles Tuesday night, the American’s back seized up and he was forced to retire early in the fourth. Should he recover in time to take the court, he and Fernandez will be a must-watch pair.

Robin Montgomery and Nick Monroe

In what will be the last tournament in a solid career, Monroe will be taking the court as much as possible (and be busy off it, too, with various Tennis Channel duties). The veteran is teaming up with Montgomery, one of the brightest prospects in US tennis. The 17-year-old might not have that much experience, but she definitely knows how to play in New York, having swept the girls’ junior titles last year.