Setting: Shanghai, quarterfinals
Ranking: No. 7 vs. No. 1
Head-to-Head: 1-1
Any time one of the Big Three gets beaten, it's a big deal. Even still, no one expected Djokovic to lose at the Shanghai Masters. The defending champion had recently won Wimbledon and then the Japan Open only a week prior.
He was (again) on a streak of dominance and, as the No. 1 seed, it looked like an easy title after sweeping aside his first two opponents in straight sets.