With the absence of John Isner, the American men weren't going to have a single seed at Roland Garros this year—until the withdrawal of Milos Raonic moved Frances Tiafoe into the No. 32 spot.
To make things even more difficult, the U.S. up-and-comers drew some tough first-round matches, and not even necessarily against seeded opponents.
Reilly Opelka, for example, pulled 22-year-old dark horse Cristian Garin, who's taken two clay titles this swing (in Houston and Munich, more than Rafael Nadal) and won 12 of his last 14 matches.