NEW YORK -- Might be best to say that Tim Smyczek, much like American men's tennis, ran out of gas Sunday night.

The 25-year-old from Milwaukee, who served up a funny headline when he told about how the car he was riding in ran out of gas en route to the U.S. Open last week, was two points away from helping his country avoid an ignominious fate.

"I never heard somebody yell out from the stands, `You're our last hope," Smyczek said.

But he could not pull through against Marcel Granollers.

He lost 6-4, 4-6, 0-6, 6-3, 7-5 to the Spaniard in front of a rowdy crowd chanting "USA! USA!" in the Grandstand, and now, the Americans don't have a single man in the round of 16 at their own Grand Slam for the first time since the tournament started in 1881.

"Couldn't be much more disappointed right now, but these are the kind of situations you dream about," Smyczek said. "It was pretty cool to be the last American in the draw for a day. Got a little taste of it."

Not that this latest American flop is all on Smyczek, who came in ranked 109th and was making his first appearance in the third round of a Grand Slam.

It was scheduling as much as anything that left him standing alone -- last among the 15 U.S. men who started this tournament -- when the lights came on Sunday night. Jack Sock and John Isner lost their third-round matches Saturday. Isner, the highest-seeded man at No. 13, withered in a four-set loss to Philipp Kohlschreiber, saying his couple of attempts to rile up the crowd in the fourth set wore him out.

In the second round, 26th-seeded Sam Querrey fell to Adrian Mannarino.

Smyczek's departure means nobody from the country that gave tennis Connors, McEnroe, Sampras, Agassi and Roddick reached the fourth round at any Grand Slam in 2013. Last month, for the first time in the 40 years of the ATP rankings, there was a week with no U.S. men in the top 20.

"I know we got really spoiled with Pete, Andre, all those guys, and Andy for so many years," Smyczek said. "But I think it's also a really exciting time because there's five, six, seven guys that are hovering right around 100 and have a good chance to make a big breakthrough."

Could Smyczek, who at 5-foot-9, sometimes jumps to power through his forehands, be the guy?

For a while during the 3-hour, 24-minute match against Granollers, it very much looked like he might be moving on to Week 2 -- and that maybe he'd be in the news for something other than the mishap he experienced before his first-round match, when the tournament-provided car he was riding in ran out of gas en route to Flushing Meadows.

"Just glad we didn't break down in the Midtown Tunnel," Smyczek joked that day.

He went on to win that match, then the next. On Sunday, he was not overmatched, as the stat sheet showed: He won one game more and one point fewer than Granollers. They each had 10 aces, three double-faults, a 113 mph average first-serve speed and 84 mph second-serve speed. But when it came to the biggest points, Granollers won most.

After losing a break after leading 4-2 in the final set slide, Smyczek had two chances to break back but couldn't convert on either. Then, four times while Granollers was serving at 5-4, Smyczek found himself two points from the match. He lost them all on a service winner, an ace (After which Smyczek used his last challenge on a ball that landed inside the line), another service winner and a looping forehand winner by the Spaniard.

Then, with Granollers serving out the match at 6-5, Smyczek failed to get one return back in play.

This marked the third time this summer that Smyczek had a one-set lead against a top-50 opponent and failed to close it out.

"I'm going to take a couple days off and maybe take a step back and think about some things and just really take the positives," he said.

Granollers, who played the role of the bad guy in a stadium packed with U.S. fans, said there's a good future for U.S. tennis. Just not on his watch -- at least not on Sunday.

"Every year is different. The quality of the game nowadays is quite even," he said. "It just happens that no one managed to get that far, but there are several talented American players, and I'm sure that they will have good results in the future."