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WATCH: Stefanos Tsitsipas came from behind upon resumption to beat Andy Murray in five sets on Centre Court.

Five sets, two days, and one familiar story for Stefanos Tsitsipas this year at Wimbledon: a marathon win.

The fifth-seeded Tsitsipas won both sets played on Friday on Centre Court to finish off a 7-6(3), 6-7(2), 4-6, 7-6(3), 6-4 comeback against two-time Wimbledon champion Andy Murray and move through to the third round at the All England Club for the second straight year.

Tsitsipas had previously beaten 2020 US Open winner Dominic Thiem in a final-set tiebreak in a blockbuster opening round that also lasted two days, but his win over Murray totaled four hours and 40 minutes in the longest match of the tournament so far.

"It's never easy against Andy. I know everyone loves him here ... I'm very impressed by how he holds up, having been so many years on the tour, having had two hip surgeries, I'm very impressed with his level," Tsitsipas said in his on-court interview. "It's extra difficult when you grow up watching him play on this court, as I said a few days ago ... I had goosebumps watching him win his first title here.

"You're facing Andy Murray on the other side of the court, and you're two-sets-to-one-down. You have to come up with solutions. You have to be careful, of course, of what you're going to pursue. That was the most challenging part today. I knew I was dealing with someone that could return a lot of balls in. He's someone who'll make it a marathon, regardless of whether you want it or not.

"I had to work extra-hard today to get that victory. My legs are sore right now. He made me run left and right, up and down, for—how many hours was that?—over four hours. it was a difficult one."

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The match between Murray and Tsitsipas, which was suspended on Thursday night due to Wimbledon's 11 p.m. curfew with Murray leading after three near-vintage sets, quickly picked up where it left off. On the second point, a scorched, running backhand passing shot also assuaged any concerns that a capacity Centre Court crowd might've had about their man, who slipped and took a hard fall on the penultimate point of the third set the previous night.

Neither man faced a break point for the duration of the fourth set—though each came close at deuce in the fourth and fifth games, and Murray, again, at 15-30 in the eighth—before a 30-shot rally at 3-3 in the eventual tiebreak, punctuated by a winning Tsitsipas smash, put momentum squarely on the shoulders of the Greek.

He broke for the first time across the five sets three games later, taking the lead for good at 2-1 in the final set. He rounded into his best form on serve in the final set, losing just eight points in five service games in it. He only faced one break point over the course of the match entirely.

British hopes were dealt a further blow nearly simultaneously on No. 1 Court, as American Chris Eubanks upset 2022 semifinalist and No.12 seed Camerona Norrie, 6-3, 3-6, 6-2, 7-6(3) to reach the third round of a major for the first time. Eubanks, who won his first career title in Mallorca last week, has now won five straight matches on grass.