Mardy Fish says that coming into the U.S. Open as the highest seeded American for the first time is significantly different for him. The No. 7 seed will open play on Monday against German Tobias Kamke.

"This is probably one of the biggest events that I'll ever play, just being in this position right now and coming in playing extremely well," Fish told reporters. "Winning the U.S. Open Series and just coming in on a high and playing great the last two events [at Montreal and Cincinnati]. It's one of those where a lot of times you kinda want to work your way into the tournament. I want to play Monday. I want to get out there and start, because it's exciting for me…[There is a] slight bit more pressure. Certainly different pressure than I've ever felt. But a great feeling. It's just one of those experiences that not everybody can go through.  I can understand just a little of what Andy [Roddick] has gone through and respect the job that he's done with it and how well he's handled the expectations with his play."