NEW YORK(AP) Andy Murray of Britain has been upset at the U.S. Open, losing in straight sets to Marin Cilic of Croatia.

The 16th-seeded Cilic beat the No. 2 Murray 7-5, 6-2, 6-2 Tuesday to reach his first Grand Slam quarterfinal.

Murray was the runner-up at Flushing Meadows last year. He appeared to have trouble with his left wrist against Cilic, flexing it and grimacing.

Cilic hit 35 winners to only 13 for Murray.

Cilic next plays No. 6 Juan Martin del Potro of Argentina.