Brandon Nakashima tops John Isner at Indian Wells minus Djokovic, Nadal

WATCH: Brandon Nakashima defeats John Isner in the 2023 Indian Wells first round

INDIAN WELLS, Calif. (AP) — Brandon Nakashima took advantage of two double-faults by John Isner in an error-filled game to collect the match's only service break and went on to reach the second round at the BNP Paribas Open with a 7-6 (7), 6-3 victory in the all-American contest Wednesday.

Kansas City Chiefs quarterback Patrick Mahomes was in the stands as play got started at the year's first Masters 1000 event, a combined tournament for women and men.

Nakashima, a 21-year-old from San Diego, saved one set point for 2018 Wimbledon semifinalist Isner, who is 37, en route to grabbing the opening tiebreaker. And Nakashima, who won the ATP Next Gen Finals last year, broke to lead 4-2 in the second set after nearly 1 1/2 hours of play, taking his four points in that game via that pair of double-faults, one forehand by Isner that found the net tape and didn't make it over, and another that sailed long.

In all, Isner, the 2012 runner-up at Indian Wells, double-faulted seven times, part of his total of 25 unforced errors — 18 more than Nakashima. Next up for the 48th-ranked Nakashima is the tough task of facing 2022 U.S. Open champion and former No. 1 Daniil Medvedev, who is on a 14-match winning streak and won the past three tournaments he entered.

That run of success includes a win over Novak Djokovic, the 22-time Grand Slam champion not in the field at Indian Wells because he can't travel to the United States as a foreign citizen not vaccinated against COVID-19. The player Djokovic shares the record with for most majors won by a man, Rafael Nadal, also isn't in the desert; he has been sidelined since injuring his left hip flexor at the Australian Open.

Medvedev, like other seeded players, received a first-round bye.

On Wednesday night, Gael Monfils — a two-time Grand Slam semifinalist who is 36 — was scheduled to compete for the first time since August, facing Jordan Thompson. Monfils hasn't played since a foot injury last August.

In other Day 1 action, Evgeniya Rodina, a 34-year-old who is ranked 427th and had played just one tour-level match in 2023, ousted 68th-ranked Alizé Cornet 6-2, 7-5; 67th-ranked Wang Xinyu beat 37th-ranked Elise Mertens 6-3, 6-1; wild-card entry Dayana Yastremska defeated Anna Bondar 6-3, 6-4; Aliaksandra Sasnovich got past Kaia Kanepi 6-3, 7-6 (5); Anna Blinkova beat Ann Li 6-1, 6-2; and 18-year-old Linda Noskova defeated Irina-Camelia Begu 7-6 (7), 6-1.

Shelby Rogers was a 6-4, 4-6, 6-1 winner in an all-American matchup against wild-card entry Katie Volynets; qualifier Lesia Tsurenko beat Zhu Lin 6-4, 6-3; and Camila Giorgi picked up a 6-3, 6-3 victory over qualifier Arantxa Rus.

In men's matches, Marcos Giron, who won an NCAA singles title for UCLA, eliminated Aleksandar Kovacevic 6-3, 7-5; Ugo Humbert beat Bernabe Zapata Miralles 6-2, 7-6 (6); Jason Kubler edged Lorenzo Sonego 6-4, 7-6 (4); and Oscar Otte defeated Laslo Djere 6-3, 7-5.

Wild-card entry Wu Yibing, whose title at Dallas last month made him the first Chinese player to win an ATP singles trophy, pulled out a 6-7 (6), 6-0, 7-6 (3) win against Jaume Munar; qualifier Taro Daniel beat Roberto Carballes Baena 6-1, 7-5 to set up a meeting with 2021 Wimbledon finalist Matteo Berrettini; qualifier Cristian Garin defeated Daniel Galan 6-4, 6-2; and Australian Open quarterfinalist Jiri Lehecka eliminated Arthur Rinderknech 7-6 (4), 7-5.