NEW YORK (AP) France's Jo-Wilfried Tsonga came back to eliminate Mardy Fish, the highest-seeded American, 6-4, 6-7 (5), 3-6, 6-4, 6-2 Monday to reach the U.S. Open quarterfinals for the first time.

No. 8 Fish was trying to make it past the fourth round at Flushing Meadows for the second time. But his play dipped in the fourth set, and he was treated by a trainer for a right leg problem before the fifth.

The 11th-seeded Tsonga's best Grand Slam showing was reaching the final of the 2008 Australian Open. He also made it to the Wimbledon semifinals this year by rallying to beat Roger Federer after dropping the first two sets.

Tsonga could face Federer again in the quarterfinals at Flushing Meadows.