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PARIS (AP) — Carlos Alcaraz's hopes of finishing the season as the top-ranked player took a hit after a 6-3, 6-4 loss to qualifier Roman Safiullin in the second round of the Paris Masters on Tuesday.

In his return from injury, Alcaraz dropped serve four times and made 27 unforced errors to 21 for Safiullin, a former world No. 2 junior.

The Spaniard was knocked out in the fourth round of the Shanghai Masters nearly three weeks ago and withdrew from the Swiss Indoors in Basel because of a left foot injury and muscle fatigue to his lower back.

Alcaraz leads the ATP Tour with six titles this year but hasn't lifted any trophy since Wimbledon. He seems to be running on fumes lately because of his demanding style of play.

The second-seeded Alcaraz and Safiullin traded breaks in the third and fourth games. Alcaraz struggled to find his range and dropped serve at 4-3 with a poor game that included a double fault and two unforced errors. Safiullin hit a service winner and two backhand winners to grab the opening set.

Play was briefly interrupted in the beginning of the second set to switch off a vivid pink light under the roof of the arena that troubled the players when they were tossing the ball to serve.

Alcaraz rifled two consecutive return winners to break for a 3-1 lead only to see Safiullin break back in the next game with a forehand pass. Alcaraz dropped serve again in the seventh game, hitting a forehand long at the end of a long rally. Safiullin converted his second match point when Alcaraz sent a forehand return long.

Last season, Alcaraz became the youngest year-end No. 1 in the history of the ATP rankings. He is looking to achieve the extraordinary feat of claiming two year-end No. 1 finishes at only 20.

Top-ranked Novak Djokovic had racked up 500 more points than Alcaraz this season before the Paris Masters.

Djokovic won't be able to clinch the year-end No. 1 spot in Paris since Alcaraz still gets 10 points for his second-round defeat.

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In his return from injury, Alcaraz (right) dropped serve four times and made 27 unforced errors to 21 for Safiullin, a former world No. 2 junior.

In his return from injury, Alcaraz (right) dropped serve four times and made 27 unforced errors to 21 for Safiullin, a former world No. 2 junior.

There are 1,000 points for the Paris Masters winner and 1,500 points for a perfect run at the ATP Finals.

Daniil Medvedev also has an outside chance of finishing the season as the No. 1 player.

The 16th-seeded Karen Khachanov, Tallon Griekspoor and Daniel Altmaier also moved into the third round. Khachanov beat Laslo Djere 6-4, 7-5, and Griekspoor routed Alejandro Davidovich Fokina 6-2, 6-2. Altmaier ousted Arthur Fils 6-2, 6-4 in the first round but got a walkover into the third round because his next opponent, Taylor Fritz, withdrew because of an abdominal strain.

The ninth-seeded Fritz received treatment on his abdomen during the second set of his first-round win over Sebastian Baez on Monday.

"Devastated to have to pull out with so much on the line," the American said on the social media platform X. "All I wanted was the chance to fight for my potential Turin spot but after getting scans today on my oblique it's just not possible for me to play. Time to rehab and hope to be back on court as soon as I can be."

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Before the Paris Masters, Djokovic, Alcaraz, Medvedev, Jannik Sinner and Andrey Rublev had already qualified for the ATP Finals, the season-ending tournament for the top eight players on tour that will be played in Turin from Nov. 12-19.

Meanwhile, Alexander Zverev and Hubert Hurkacz stayed in contention for the three remaining spots at the ATP Finals by advancing to the second round.

The 10th-seeded Zverev rallied past qualifier Marton Fucsovics 4-6, 7-5, 6-4, while Hurkacz overcame Sebastian Korda 6-3, 6-7 (6), 6-3.

Felix Auger-Aliassime, Francisco Cerundolo, Ugo Humbert, Tomas Martin Etcheverry, Mackenzie McDonald and Dusan Lajovic also won their first-round matches.

Etcheverry outlasted Miomir Kecmanovic 4-6, 7-6 (6), 6-4 by saving a match point to set up a meeting with top-seeded Djokovic.

Djokovic warmed up by playing in doubles with Kecmanovic on Tuesday. The Serbian pair beat Gonzalo Escobar and Aleksandr Nedovyesov 6-4, 6-2 in the first round.

Cerundolo also saved a match point to edge Gael Monfils 4-6, 7-6 (2), 7-5.